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Article

Application of a pharmacokinetic/pharmacogenetic approach to assess the nicotine metabolic profile of smokers in the real-life setting.

Journal of pharmaceutical and biomedical analysis - 30 Nov 2016

Fogli Stefano, Saba Alessandro, Del Re Marzia, Pistelli Francesco, Aquilini Ferruccio, Zucchi Riccardo, Palla Antonio, Breschi Maria Cristina, Carrozzi Laura, Danesi Romano

Abstract excerpt

The nicotine metabolite ratio, i.e., the ratio 3-hydroxycotinine/cotinine, is used to assess the nicotine metabolic status and has been proven to predict the response to smoking cessation treatments in randomized clinical trials. In the current study, a pharmacokinetic-pharmacogenetic integrated approach is described, based on the development of a liquid chromatography-tandem mass spectrometry (LC/MS/MS) method...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27599351
DOI: 10.1016/j.jpba.2016.08.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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