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Article

Aristolochic acid nephropathy: Harbinger of a global iatrogenic disease.

Environmental and molecular mutagenesis - 1 Jan 2013

Grollman Arthur P

Abstract excerpt

This review constitutes an overview of our investigations of aristolochic acid nephropathy, a chronic kidney disease associated with carcinomas of the upper urinary tract. Our studies began by confirming the hypothesis that chronic dietary poisoning by aristolochic acid was responsible for endemic (Balkan) nephropathy. A unique TP53 mutational signature in urothelial tumors and the presence of aristolactam-DNA...

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Identifiers

PMID: 23238808
DOI: 10.1002/em.21756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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