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Article

A quadratically regularized functional canonical correlation analysis for identifying the global structure of pleiotropy with NGS data.

PLoS computational biology - 1 Oct 2017

Lin Nan, Zhu Yun, Fan Ruzong, Xiong Momiao

Abstract excerpt

Investigating the pleiotropic effects of genetic variants can increase statistical power, provide important information to achieve deep understanding of the complex genetic structures of disease, and offer powerful tools for designing effective treatments with fewer side effects. However, the current multiple phenotype association analysis paradigm lacks breadth (number of phenotypes and genetic variants jointly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29040274
DOI: 10.1371/journal.pcbi.1005788
PMCID: PMC5659802

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