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Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor.

Molecular microbiology - 1 Aug 2012

Yu Zhenyu, Zhu Hong, Dang Fujun, Zhang Weiwen, Qin Zhongjun, Yang Sheng, Tan Huarong, Lu Yinhua, Jiang Weihong

Abstract excerpt

A novel two-component system (TCS) designated as DraR-K (sco3063/sco3062) was identified to be involved in differential regulation of antibiotic biosynthesis in Streptomyces coelicolor. The S. coelicolor mutants with deletion of either or both of draR and draK exhibited significantly reduced actinorhodin (ACT) but increased undecylprodigiosin (RED) production on minimal medium (MM) supplemented separately with...

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PMID: 22676800
DOI: 10.1111/j.1365-2958.2012.08126.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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