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Article

Improved detection of genetic loci in estimated glomerular filtration rate and type 2 diabetes using a pleiotropic cFDR method.

Molecular genetics and genomics : MGG - 1 Feb 2018

Liu Hui-Min, He Jing-Yang, Zhang Qiang, Lv Wan-Qiang, Xia Xin, Sun Chang-Qing, Zhang Wei-Dong, Deng Hong-Wen

Abstract excerpt

Genome-wide association studies (GWAS) have been shown to have the potential of explaining more of the "missing heritability" of complex human phenotypes by improving statistical approaches. Here, we applied a genetic-pleiotropy-informed conditional false discovery rate (cFDR) to capture additional polygenic effects associated with estimated glomerular filtration rate (creatinine) (eGFRcrea) and type 2 diabetes...

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Share to Diabetes Mellitus, Type 2
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 29038864
DOI: 10.1007/s00438-017-1381-6
PMCID: PMC5819009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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