Article
A genome-wide search for linkage of estimated glomerular filtration rate (eGFR) in the Family Investigation of Nephropathy and Diabetes (FIND).
PloS one - 1 Jan 2013
Thameem Farook, Igo Robert P, Freedman Barry I, Langefeld Carl, Hanson Robert L, Schelling Jeffrey R, Elston Robert C, Duggirala Ravindranath, Nicholas Susanne B, Goddard Katrina A B, Divers Jasmin, Guo Xiuqing, Ipp Eli, Kimmel Paul L, Meoni Lucy A, Shah Vallabh O, Smith Michael W, Winkler Cheryl A, Zager Philip G, Knowler William C, Nelson Robert G, Pahl Madeline V, Parekh Rulan S, Kao W H Linda, Rasooly Rebekah S, Adler Sharon G, Abboud Hanna E, Iyengar Sudha K, Sedor John R
Abstract excerpt
OBJECTIVE: Estimated glomerular filtration rate (eGFR), a measure of kidney function, is heritable, suggesting that genes influence renal function. Genes that influence eGFR have been identified through genome-wide association studies. However, family-based linkage approaches may identify loci that explain a larger proportion of the heritability. This study used genome-wide linkage and association scans to...
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