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Article

Powerful and robust inference of complex phenotypes' causal genes with dependent expression quantitative loci by a median-based Mendelian randomization.

American journal of human genetics - 5 May 2022

Jiang Lin, Miao Lin, Yi Guorong, Li Xiangyi, Xue Chao, Li Mulin Jun, Huang Hailiang, Li Miaoxin

Abstract excerpt

Isolating the causal genes from numerous genetic association signals in genome-wide association studies (GWASs) of complex phenotypes remains an open and challenging question. In the present study, we proposed a statistical approach, the effective-median-based Mendelian randomization (MR) framework, for inferring the causal genes of complex phenotypes with the GWAS summary statistics (named EMIC). The...

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Identifiers

PMID: 35460606
DOI: 10.1016/j.ajhg.2022.04.004
PMCID: PMC9118119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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