Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of a dengue NS4B inhibitor originating from an HCV small molecule library.

Antiviral research - 1 Nov 2017

Hernandez-Morales Ilane, Geluykens Peggy, Clynhens Marleen, Strijbos Rudy, Goethals Olivia, Megens Sarah, Verheyen Nick, Last Stefaan, McGowan David, Coesemans Erwin, De Boeck Benoît, Stoops Bart, Devogelaere Benoit, Pauwels Frederik, Vandyck Koen, Berke Jan Martin, Raboisson Pierre, Simmen Kenneth, Lory Pedro, Van Loock Marnix

Abstract excerpt

Dengue is the most important mosquito-transmitted viral disease and a major global health concern. Over the last decade, dengue virus (DENV) drug discovery and development has intensified, however, this has not resulted in approved DENV-specific antiviral treatments yet. DENV and hepatitis C virus (HCV) belong to the same Flaviviridae family and, in contrast to DENV, antiviral treatments for HCV have been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dengue
Share to Dengue Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Discovery

Share to Replicon

Share to Sequence Analysis, RNA

Share to Small Molecule Libraries

Share to Vero Cells

Share to Viral Nonstructural Proteins

Source

Identifiers

PMID: 29037976
DOI: 10.1016/j.antiviral.2017.10.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a dengue NS4B inhibitor originating from an HCV small molecule library.PMID 29037976Read ↗

Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymeraseSemantic proximity Read ↗

Identification of Compound-B, a novel anti-dengue virus agent targeting the non-structural protein 4A.Semantic proximity Read ↗

Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication.Semantic proximity Read ↗

Inhibition of Dengue Virus by Targeting Viral NS4B ProteinSemantic proximity Read ↗

A Novel Dengue Virus Inhibitor, BP13944, Discovered by High-Throughput Screening with Dengue Virus Replicon Cells Selects for Resistance in the Viral NS2B/NS3 ProteaseSemantic proximity Read ↗

Discovery of Dengue Virus NS4B InhibitorsSemantic proximity Read ↗

Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors.Semantic proximity Read ↗

Characterization of an efficient dengue virus replicon for development of assays of discovery of small molecules against dengue virusSemantic proximity Read ↗

Identification of a small-molecule inhibitor of dengue virus using a replicon systemSemantic proximity Read ↗

Resistance studies of a dithiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems.Semantic proximity Read ↗

A screen for novel hepatitis C virus RdRp inhibitor identifies a broad-spectrum antiviral compound.Semantic proximity Read ↗

A Review on the Progress and Prospects of Dengue Drug Discovery Targeting NS5 RNA- Dependent RNA PolymeraseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.