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Inhibition of Dengue Virus by Targeting Viral NS4B Protein

25 Aug 2011

Abstract excerpt

We report a novel inhibitor that selectively suppresses dengue virus (DENV) by targeting viral NS4B protein. The inhibitor was identified by screening a 1.8-million-compound library using a luciferase replicon of DENV serotype 2 (DENV-2). The compound specifically inhibits all four serotypes of DENV (50% effective concentration [EC(50)], 1 to 4 μM; and 50% cytotoxic concentration [CC(50)], >40 μM), but it does...

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Identifiers

PMID: 21865382
DOI: 10.1128/jvi.05468-11

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