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Article

Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication.

Antiviral research - 1 Aug 2013

van Cleef Koen W R, Overheul Gijs J, Thomassen Michael C, Kaptein Suzanne J F, Davidson Andrew D, Jacobs Michael, Neyts Johan, van Kuppeveld Frank J M, van Rij Ronald P

Abstract excerpt

Dengue virus (DENV) is an important human arthropod-borne virus with a major impact on public health. Nevertheless, a licensed vaccine or specific treatment is still lacking. We therefore screened the NIH Clinical Collection (NCC), a library of drug-like small molecules, for inhibitors of DENV replication using a cell line that contains a stably replicating DENV serotype 2 (DENV2) subgenomic replicon. The most...

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PMID: 23735301
DOI: 10.1016/j.antiviral.2013.05.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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