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Article

A screen for novel hepatitis C virus RdRp inhibitor identifies a broad-spectrum antiviral compound.

Scientific reports - 19 Jul 2017

Madhvi Abhilasha, Hingane Smita, Srivastav Rajpal, Joshi Nishant, Subramani Chandru, Muthumohan Rajagopalan, Khasa Renu, Varshney Shweta, Kalia Manjula, Vrati Sudhanshu, Surjit Milan, Ranjith-Kumar C T

Abstract excerpt

Hepatitis C virus (HCV) is a global pathogen and infects more than 185 million individuals worldwide. Although recent development of direct acting antivirals (DAA) has shown promise in HCV therapy, there is an urgent need for the development of more affordable treatment options. We initiated this study to identify novel inhibitors of HCV through screening of compounds from the National Cancer Institute (NCI)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28725041
DOI: 10.1038/s41598-017-04449-3
PMCID: PMC5517564

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