Article
Identification of Compound-B, a novel anti-dengue virus agent targeting the non-structural protein 4A.
Antiviral research - 1 Jul 2018
Nobori Haruaki, Toba Shinsuke, Yoshida Ryu, Hall William W, Orba Yasuko, Sawa Hirofumi, Sato Akihiko
Abstract excerpt
Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic fever/dengue shock syndrome. At present, no antiviral drugs are available for treatment DENV infections. In this study, a screening system based on a DENV-infected cell-based assay identified a novel anti-DENV agent with a benzimidazole skeleton, named Compound-B, which demonstrated antiviral activity specific to four DENV serotypes...
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