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Article

Discovery of Dengue Virus NS4B Inhibitors

28 May 2015

Abstract excerpt

ABSTRACT The four serotypes of dengue virus (DENV-1 to -4) represent the most prevalent mosquito-borne viral pathogens in humans. No clinically approved vaccine or antiviral is currently available for DENV. Here we report a spiropyrazolopyridone compound that potently inhibits DENV both in vitro and in vivo . The inhibitor was identified through screening of a 1.8-million-compound library by using a DENV-2...

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Identifiers

PMID: 26018165
DOI: 10.1128/jvi.00855-15

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