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Article

Divalent copper complexes as influenza A M2 inhibitors.

Antiviral research - 1 Nov 2017

Gordon Nathan A, McGuire Kelly L, Wallentine Spencer K, Mohl Gregory A, Lynch Jonathan D, Harrison Roger G, Busath David D

Abstract excerpt

New M2 blockers effective against the ubiquitous amantadine-resistant S31N M2 mutation in influenza A are needed. Six copper complexes, 2, 4, 6, 8, 9, and 10, were synthesized and found to block both wild type and S31N M2. Free Cu2+ also blocks M2 S31N but not S31N/H37A. The copper complexes do not block M2 H37A (either S31 or S31N). The complexes were effective against three influenza A strains in cell-culture...

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Identifiers

PMID: 29032206
DOI: 10.1016/j.antiviral.2017.10.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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