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Article

Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus.

European journal of medicinal chemistry - 27 Jan 2016

Dong Jianghong, Chen Shengwei, Li Runfeng, Cui Wei, Jiang Haiming, Ling Yixia, Yang Zifeng, Hu Wenhui

Abstract excerpt

We previously reported potent hit compound 4 inhibiting the wild-type influenza A virus A/HK/68 (H3N2) and A/M2-S31N mutant viruses A/WS/33 (H1N1), with its latter activity quite weak. To further increase its potency, a structure-activity relationship study of a series of imidazole-linked pinanamine derivatives was conducted by modifying the imidazole ring of this compound. Several compounds of this series...

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Identifiers

PMID: 26722757
DOI: 10.1016/j.ejmech.2015.12.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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