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Article

Constitutive Ret signaling leads to long-lasting expression of amphetamine-induced place conditioning via elevation of mesolimbic dopamine.

Neuropharmacology - 1 Jan 2018

Kopra Jaakko, Villarta-Aguilera Marian, Savolainen Mari, Weingerl Samo, Myöhänen Timo T, Rannanpää Saara, Salvatore Michael F, Andressoo Jaan-Olle, Piepponen T Petteri

Abstract excerpt

Addictive drugs enhance dopamine release in the striatum, which can lead to compulsive drug-seeking after repeated exposure. Glial cell line-derived neurotrophic factor (GDNF) is an important regulator of midbrain dopamine neurons, and may play a mechanistic role in addiction-related behaviors. To elucidate the components of GDNF-signaling that contribute to addiction-related behaviors of place preference and its...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29031851
DOI: 10.1016/j.neuropharm.2017.10.010
PMCID: PMC6104196

Genes

GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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