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Article

Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model

25 Apr 2016

Abstract excerpt

This study provides a demonstration in the rat of a clear genetic difference in the propensity for addiction-related behaviors following prolonged cocaine self-administration. It relies on the use of selectively bred high-responder (bHR) and low-responder (bLR) rat lines that differ in several characteristics associated with "temperament," including novelty-induced locomotion and impulsivity. We show that bHR...

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PMID: 27114539
DOI: 10.1073/pnas.1520491113

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