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Article

Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine.

Cell - 19 Sept 1997

Rubinstein M, Phillips T J, Bunzow J R, Falzone T L, Dziewczapolski G, Zhang G, Fang Y, Larson J L, McDougall J A, Chester J A, Saez C, Pugsley T A, Gershanik O, Low M J, Grandy D K

Abstract excerpt

The human dopamine D4 receptor (D4R) has received considerable attention because of its high affinity for the atypical antipsychotic clozapine and the unusually polymorphic nature of its gene. To clarify the in vivo role of the D4R, we produced and analyzed mutant mice (D4R-/-) lacking this protein. Although less active in open field tests, D4R-/- mice outperformed wild-type mice on the rotarod and displayed...

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Identifiers

PMID: 9323127
DOI: 10.1016/s0092-8674(00)80365-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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