Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine.

doi:10.1016/s0092-8674(00)80365-7

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine.

Cell - 19 Sept 1997

Rubinstein M, Phillips T J, Bunzow J R, Falzone T L, Dziewczapolski G, Zhang G, Fang Y, Larson J L, McDougall J A, Chester J A, Saez C, Pugsley T A, Gershanik O, Low M J, Grandy D K

Abstract excerpt

The human dopamine D4 receptor (D4R) has received considerable attention because of its high affinity for the atypical antipsychotic clozapine and the unusually polymorphic nature of its gene. To clarify the in vivo role of the D4R, we produced and analyzed mutant mice (D4R-/-) lacking this prote...

Topics

3,4-Dihydroxyphenylacetic Acid
Amino Acid Sequence
Animals
Antipsychotic Agents
Behavior, Animal
Central Nervous System Depressants
Clozapine
Cocaine
Corpus Striatum
Dopamine
Dopamine Agents
Ethanol
Genotype
Humans

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Levodopa

Locomotion

Maternal Behavior

Methamphetamine

Source

Open in PubMed

Identifiers

PMID: 9323127
DOI: 10.1016/s0092-8674(00)80365-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9323127-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.