Effect of GDNF on depressive-like behavior, spatial learning and key genes of the brain dopamine system in genetically predisposed to behavioral disorders mouse strains.

doi:10.1016/j.bbr.2014.07.045

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Article

Effect of GDNF on depressive-like behavior, spatial learning and key genes of the brain dopamine system in genetically predisposed to behavioral disorders mouse strains.

Behavioural brain research - 1 Nov 2014

Naumenko Vladimir S, Kondaurova Elena M, Bazovkina Daria V, Tsybko Anton S, Ilchibaeva Tatyana V, Khotskin Nikita V, Semenova Alina A, Popova Nina K

Abstract excerpt

The effect of glial cell line-derived neurotrophic factor (GDNF) on behavior and brain dopamine system in predisposed to depressive-like behavior ASC (Antidepressant Sensitive Cataleptics) mice in comparison with the parental "nondepressive" CBA mice was studied. In 7days after administration (800ng, i.c.v.) GDNF decreased escape latency time and the path traveled to reach hidden platform in Morris water maze in...

Topics

Animals
Behavioral Symptoms
Brain
Catechol O-Methyltransferase
Dopamine
Dopamine Agents
Gene Expression Regulation
Genetic Predisposition to Disease
Glial Cell Line-Derived Neurotrophic Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hindlimb Suspension

Male

Maze Learning

Mice

Mice, Inbred CBA

Mice, Mutant Strains

Monoamine Oxidase

Reaction Time

Spatial Behavior

Source

Open in PubMed

Identifiers

PMID: 25101543
DOI: 10.1016/j.bbr.2014.07.045

Genes

GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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