Article
An in silico modeling approach to understanding the dynamics of sarcoidosis.
PloS one - 1 Jan 2011
Aguda Baltazar D, Marsh Clay B, Thacker Michael, Crouser Elliott D
Abstract excerpt
BACKGROUND: Sarcoidosis is a polygenic disease with diverse phenotypic presentations characterized by an abnormal antigen-mediated Th1 type immune response. At present, progress towards understanding sarcoidosis disease mechanisms and the development of novel treatments is limited by constraints attendant to conducting human research in a rare disease in the absence of relevant animal models. We sought to develop...
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