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Regulation of CD4 + T‐cell polarization by suppressor of cytokine signalling proteins

12 Oct 2011

Abstract excerpt

Suppressors of cytokine signalling (SOCS) proteins are induced in responses to many stimuli and by binding to cytokine receptors and associated janus kinase (JAK) proteins, directly regulate the activation of the signal transducers and activators of transcription (STATs). STAT proteins regulate the expression of many genes required for the differentiation of various CD4(+) T helper cell lineages, and there is now...

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PMID: 22044277
DOI: 10.1111/j.1365-2567.2011.03520.x

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