Article
Biopsy-derived Intestinal Epithelial Cell Cultures for Pathway-based Stratification of Patients With Inflammatory Bowel Disease.
Journal of Crohn's & colitis - 24 Jan 2018
Vanhove Wiebe, Nys Kris, Arijs Ingrid, Cleynen Isabelle, Noben Manuel, De Schepper Sebastiaan, Van Assche Gert, Ferrante Marc, Vermeire Séverine
Abstract excerpt
BACKGROUND: Endoplasmic reticulum [ER] stress was shown to be pivotal in the pathogenesis of inflammatory bowel disease. Despite progress in inflammatory bowel disease [IBD] drug development, not more than one-third of patients achieve steroid-free remission and mucosal healing with current therapies. Furthermore, patient stratification tools for therapy selection are lacking. We aimed to identify and quantify...
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