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Article

c-Abl regulates gastrointestinal muscularis propria homeostasis via ERKs.

Scientific reports - 15 Jun 2017

Xiang Jinnan, Zhang Yiqun, Bao Dandan, Cao Na, Zhang Xin, Li Ping, Qiu Shoutao, Guo Jigang, He Dan, Li Baojie, Yao Liqing, Liu Huijuan

Abstract excerpt

The gastrointestinal tract is responsible for food digestion and absorption. The muscularis propria propels the foodstuff through the GI tract and defects in intestine motility may cause obstruction disorders. Our present genetic studies identified non-receptor tyrosine kinase c-Abl as an important regulator of the muscularis propria homeostasis and a risk factor for rectal prolapse. Mouse deficient for c-Abl...

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Identifiers

PMID: 28620185
DOI: 10.1038/s41598-017-03569-0
PMCID: PMC5472598

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