Article
A RAC-GEF network critical for early intestinal tumourigenesis.
Nature communications - 4 Jan 2021
Pickering K A, Gilroy K, Cassidy J W, Fey S K, Najumudeen A K, Zeiger L B, Vincent D F, Gay D M, Johansson J, Fordham R P, Miller B, Clark W, Hedley A, Unal E B, Kiel C, McGhee E, Machesky L M, Nixon C, Johnsson A E, Bain M, Strathdee D, van Hoof S R, Medema J P, Anderson K I, Brachmann S M, Stucke V M, Malliri A, Drysdale M, Turner M, Serrano L, Myant K, Campbell A D, Sansom O J
Abstract excerpt
RAC1 activity is critical for intestinal homeostasis, and is required for hyperproliferation driven by loss of the tumour suppressor gene Apc in the murine intestine. To avoid the impact of direct targeting upon homeostasis, we reasoned that indirect targeting of RAC1 via RAC-GEFs might be effective. Transcriptional profiling of Apc deficient intestinal tissue identified Vav3 and Tiam1 as key targets. Deletion of...
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