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Article

Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the interleukin-1 receptor family.

Cancer research - 1 Jul 2007

Garlanda Cecilia, Riva Federica, Veliz Tania, Polentarutti Nadia, Pasqualini Fabio, Radaelli Enrico, Sironi Marina, Nebuloni Manuela, Zorini Elisabetta Omodeo, Scanziani Eugenio, Mantovani Alberto

Abstract excerpt

TIR8 (also known as SIGIRR) is a member of the interleukin-1/Toll-like receptor family with inhibitory activity on inflammatory reactions and high expression in intestinal mucosa. Here, we report that Tir8-deficient mice exhibited a dramatic intestinal inflammation in response to dextran sulfate...

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Source

Identifiers

PMID: 17616656
DOI: 10.1158/0008-5472.CAN-07-0560

Genes

SIGIRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17616656-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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