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Article

Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation.

The Journal of clinical investigation - 1 Nov 2004

Yan Fang, John Sutha K, Wilson Guinn, Jones David S, Washington M Kay, Polk D Brent

Abstract excerpt

TNF plays a pathogenic role in inflammatory bowel diseases (IBDs), which are characterized by altered cytokine production and increased intestinal epithelial cell apoptosis. In vitro studies suggest that kinase suppressor of Ras-1 (KSR1) is an essential regulatory kinase for TNF-stimulated survival pathways in intestinal epithelial cell lines. Here we use a KSR1-deficient mouse model to study the role of KSR1 in...

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Source

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Identifiers

PMID: 15520859
DOI: 10.1172/JCI21022
PMCID: PMC524224

Genes

KSR1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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