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Article

Gefitinib inhibits M2-like polarization of tumor-associated macrophages in Lewis lung cancer by targeting the STAT6 signaling pathway.

Acta pharmacologica Sinica - 1 Nov 2017

Tariq Muhammad, Zhang Jie-Qiong, Liang Gui-Kai, He Qiao-Jun, Ding Ling, Yang Bo

Abstract excerpt

M2-like polarized tumor-associated macrophages (TAMs) play a pivotal role in promoting cancer cell growth, invasion, metastasis and angiogenesis. The identification of M2-like TAMs during tumor progression is an attractive approach for cancer therapy. In this study, we investigated the relevance of macrophage polarization and the antitumor effect of gefitinib in Lewis Lung cancer (LLC) in vitro and in vivo....

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Identifiers

PMID: 29022575
DOI: 10.1038/aps.2017.124
PMCID: PMC5672074

Genes

STAT6
CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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