Article
E3 ligase FBXW7 restricts M2-like tumor-associated macrophage polarization by targeting c-Myc.
Aging - 1 Dec 2020
Zhong Lijia, Zhang Yuanyuan, Li Mengyao, Song Yinjing, Liu Danhui, Yang Xin, Yang Dehua, Qu Hao, Lai Lihua, Wang Qingqing, Chen Zhimin
Abstract excerpt
FBXW7 functions as an E3 ubiquitin ligase to mediate oncoprotein degradation via the ubiquitin-proteasome system in cancer cells, effectively inhibiting the growth and survival of tumor cells. However, little is known about the functions of FBXW7 in macrophages and the tumor immune microenvironment. In this study, we find that FBXW7 suppresses M2-like tumor-associated macrophage (TAM) polarization to limit tumor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.