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Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma.

Molecular cancer therapeutics - 1 Aug 2017

Ao Jian-Yang, Zhu Xiao-Dong, Chai Zong-Tao, Cai Hao, Zhang Yuan-Yuan, Zhang Ke-Zhi, Kong Ling-Qun, Zhang Ning, Ye Bo-Gen, Ma De-Ning, Sun Hui-Chuan

Abstract excerpt

Colony-stimulating factor-1 (CSF-1) and its receptor, CSF-1R, regulate the differentiation and function of macrophages and play an important role in macrophage infiltration in the context of hepatocellular carcinoma. The therapeutic effects of CSF-1R blockade in hepatocellular carcinoma remain unclear. In this study, we found that CSF-1R blockade by PLX3397, a competitive inhibitor with high specificity for...

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PMID: 28572167
DOI: 10.1158/1535-7163.MCT-16-0866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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