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Article

Accumulated mutations by 6 months of infection collectively render transmitted/founder HIV-1 significantly less fit.

The Journal of infection - 1 Feb 2020

Wang Chu, Liu Donglai, Zuo Tao, Hora Bhavna, Cai Fangping, Ding Haitao, Kappes John, Ochsenbauer Christina, Kong Wei, Yu Xianghui, Bhattacharya Tanmoy, Perelson Alan S, Gao Feng

Abstract excerpt

OBJECTIVE: Viral fitness plays an important role in HIV-1 evolution, transmission and pathogenesis. However, how mutations accumulated during early infection affect viral fitness has not been well studied. METHODS: Paired infectious molecular clones (IMCs) for transmitted/founder (T/F) and 6-month (6-mo) viruses post infection were generated from 10 infected individuals to investigate the impact of accumulated...

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Identifiers

PMID: 31812703
DOI: 10.1016/j.jinf.2019.12.001
PMCID: PMC7010540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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