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Article

Differential extracellular signal-regulated kinases 1 and 2 activation by the angiotensin type 1 receptor supports distinct phenotypes of cardiac myocytes.

Basic & clinical pharmacology & toxicology - 1 May 2007

Aplin Mark, Christensen Gitte Lund, Schneider Mikael, Heydorn Arne, Gammeltoft Steen, Kjølbye Anne Louise, Sheikh Søren P, Hansen Jakob Lerche

Abstract excerpt

The angiotensin II (AngII) type 1 receptor (AT(1)R) is a seven-transmembrane receptor well established to activate extracellular signal-regulated kinases 1 and 2 (ERK1/2) by discrete G protein-dependent and beta-arrestin2-dependent pathways. The biological importance of this, however, remains obscure. Application of the modified analogue [Sar(1), Ile(4), Ile(8)]-AngII ([SII] AngII) allowed us to dissect the two...

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Identifiers

PMID: 17448114
DOI: 10.1111/j.1742-7843.2007.00064.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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