Article
Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.
The Journal of clinical investigation - 1 Sept 2007
Noma Takahisa, Lemaire Anthony, Naga Prasad Sathyamangla V, Barki-Harrington Liza, Tilley Douglas G, Chen Juhsien, Le Corvoisier Philippe, Violin Jonathan D, Wei Huijun, Lefkowitz Robert J, Rockman Howard A
Abstract excerpt
Deleterious effects on the heart from chronic stimulation of beta-adrenergic receptors (betaARs), members of the 7 transmembrane receptor family, have classically been shown to result from Gs-dependent adenylyl cyclase activation. Here, we identify a new signaling mechanism using both in vitro and in vivo systems whereby beta-arrestins mediate beta1AR signaling to the EGFR. This beta-arrestin-dependent...
Topics
- Animals
- Arrestins
- Cell Line
- ErbB Receptors
- Heart
- Humans
- Mice
- Mice, Transgenic
- Mutation
- Myocardium
- Phosphorylation