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Multigene Panel Testing Increases the Number of Loci Associated with Gastric Cancer Predisposition

11 Sept 2019

Abstract excerpt

The main gene involved in gastric cancer (GC) predisposition is CDH1, the pathogenic variants of which are associated with diffuse-type gastric cancer (DGC) and lobular breast cancer (LBC). CDH1 only explains a fraction (10–50%) of patients suspected of DGC/LBC genetic predisposition. To identify novel susceptibility genes, thus improving the management of families at risk, we performed a multigene panel testing...

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PMID: 31514334
DOI: 10.3390/cancers11091340

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