Article
Multiobjective differential evolution-based multifactor dimensionality reduction for detecting gene-gene interactions.
Scientific reports - 9 Oct 2017
Yang Cheng-Hong, Chuang Li-Yeh, Lin Yu-Da
Abstract excerpt
Epistasis within disease-related genes (gene-gene interactions) was determined through contingency table measures based on multifactor dimensionality reduction (MDR) using single-nucleotide polymorphisms (SNPs). Most MDR-based methods use the single contingency table measure to detect gene-gene interactions; however, some gene-gene interactions may require identification through multiple contingency table...
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