Article
Fuzzy-Based Multiobjective Multifactor Dimensionality Reduction for Epistasis Analysis.
IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000
Yang Cheng-Hong, Huang Hsiu-Chen, Hou Ming-Feng, Chuang Li-Yeh, Lin Yu-Da
Abstract excerpt
Epistasis detection is vital for understanding disease susceptibility in genetics. Multiobjective multifactor dimensionality reduction (MOMDR) was previously proposed to detect epistasis. MOMDR was performed using binary classification to distinguish the high-risk (H) and low-risk (L) groups to reduce multifactor dimensionality. However, the binary classification does not reflect the uncertainty of the H and L...
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