Article
Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions.
Bioinformatics (Oxford, England) - 12 Feb 2003
Hahn Lance W, Ritchie Marylyn D, Moore Jason H
Abstract excerpt
MOTIVATION: Polymorphisms in human genes are being described in remarkable numbers. Determining which polymorphisms and which environmental factors are associated with common, complex diseases has become a daunting task. This is partly because the effect of any single genetic variation will likely be dependent on other genetic variations (gene-gene interaction or epistasis) and environmental factors...
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