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Article

Alternative contingency table measures improve the power and detection of multifactor dimensionality reduction.

BMC bioinformatics - 16 May 2008

Bush William S, Edwards Todd L, Dudek Scott M, McKinney Brett A, Ritchie Marylyn D

Abstract excerpt

BACKGROUND: Multifactor Dimensionality Reduction (MDR) has been introduced previously as a non-parametric statistical method for detecting gene-gene interactions. MDR performs a dimensional reduction by assigning multi-locus genotypes to either high- or low-risk groups and measuring the percentage of cases and controls incorrectly labelled by this classification - the classification error. The combination of...

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PMID: 18485205
DOI: 10.1186/1471-2105-9-238
PMCID: PMC2412877

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