Article
Class Balanced Multifactor Dimensionality Reduction to Detect Gene-Gene Interactions.
IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000
Yang Cheng-Hong, Lin Yu-Da, Chuang Li-Yeh
Abstract excerpt
Detecting gene-gene interactions in single-nucleotide polymorphism data is vital for understanding disease susceptibility. However, existing approaches may be limited by the sample size in case-control studies. Herein, we propose a balance approach for the multifactor dimensionality reduction (BMDR) method to increase the accuracy of estimates of the prediction error rate in small samples. BMDR explicitly selects...
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