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Article

A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis

28 Jan 2025

Abstract excerpt

Common genetic variants in a conserved cis-regulatory element (CRE) at histone deacetylase (HDAC)9 are a major risk factor for cardiovascular disease, including stroke and coronary artery disease. Given the consistency of this association and its proinflammatory properties, we examined the mechanisms whereby HDAC9 regulates vascular inflammation. HDAC9 bound and mediated deacetylation of NLRP3 in the NACHT and...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39879983
DOI: 10.1016/j.immuni.2025.01.003

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