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Article

Tryptophan-Derived 3-Hydroxyanthranilic Acid Contributes to Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice In Vivo.

Circulation - 5 Dec 2017

Wang Qiongxin, Ding Ye, Song Ping, Zhu Huaiping, Okon Imoh, Ding Yang-Nan, Chen Hou-Zao, Liu De-Pei, Zou Ming-Hui

Abstract excerpt

BACKGROUND: Abnormal amino acid metabolism is associated with vascular disease. However, the causative link between dysregulated tryptophan metabolism and abdominal aortic aneurysm (AAA) is unknown. METHODS: Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism. Mice with deficiencies in both apolipoprotein e (Apoe) and IDO (Apoe-/-/IDO-/-) were...

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Identifiers

PMID: 28978552
DOI: 10.1161/CIRCULATIONAHA.117.030972
PMCID: PMC5716872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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