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Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes

1 Jan 2015

Abstract excerpt

Preeclampsia is a cardiovascular disorder of late pregnancy that is, commonly characterized by hypertension, renal structural damage and dysfunction, and fetal growth restriction. Prevailing etiologic models of this disorder include T-cell dysfunction as an initiating cause of preeclampsia. Indoleamine 2,3-dioxygenase (IDO), an enzyme that mediates the conversion of tryptophan to kynurenine, has been linked to...

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PMID: 25602015
DOI: 10.14814/phy2.12257

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