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Article

Dysregulation of Tryptophan Catabolism in Metabolic Syndrome

6 Feb 2018

Abstract excerpt

Objective: Obesity and metabolic syndrome are preventable complex-multifactorial disorders that severely increase risk of cardiovascular disease (CVD). Indoleamine 2,3-dioxygenase (IDO) enzyme converts tryptophan (TRP) to kynurenine (KYN); besides, KYN/TRP ratio has been shown to predict major coronary events and all-cause mortality in patients with coronary artery disease. However, their role in metabolic...

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PMID: 29406815
DOI: 10.1089/met.2017.0097

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