The causal association between plasma amino acid levels and abdominal aortic aneurysm: insights from Mendelian randomization and an experimental validation.

Abstract excerpt

Abdominal aortic aneurysm (AAA) is a severe vascular condition with a high mortality rate upon rupture. Emerging evidence suggests that metabolic factors, particularly plasma amino acids, may influence AAA risk, though specific causal roles remain unclear. This study investigates the causal relationship between plasma amino acids and AAA using Mendelian randomization (MR) and in vivo validation. A bidirectional...

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