Article
Neutrophil extracellular traps induce abdominal aortic aneurysm formation by promoting the synthetic and proinflammatory smooth muscle cell phenotype via Hippo-YAP pathway.
Translational research : the journal of laboratory and clinical medicine - 1 May 2023
Yang Shuofei, Chen Liang, Wang Zheyu, Chen Jiaquan, Ni Qihong, Guo Xiangjiang, Liu Wanfeng, Lv Lei, Xue Guanhua
Abstract excerpt
The neutrophil plays an important role during abdominal aortic aneurysm (AAA) formation by undergoing histone citrullination with peptidyl arginine deiminase 4 (encoded by Padi4) and releasing neutrophil extracellular traps (NETs). However, the specific role of NETs during AAA formation is elusive. We found the levels of NET components in serum and tissues were found to be significantly associated with the...
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