Article
Reduced Nhe1 (Na+-H+ Exchanger-1) Function Protects ApoE-Deficient Mice From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysms.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 2020
Liu Cong-Lin, Liu Xin, Wang Yunzhe, Deng Zhiyong, Liu Tianxiao, Sukhova Galina K, Wojtkiewicz Gregory R, Tang Rui, Zhang Jin-Ying, Achilefu Samuel, Nahrendorf Matthias, Libby Peter, Wang Xiaofang, Shi Guo-Ping
Abstract excerpt
IgE-mediated activation of Nhe1 (Na+-H+ exchanger-1) induces aortic cell extracellular acidification and promotes cell apoptosis. A pH-sensitive probe pHrodo identified acidic regions at positions of macrophage accumulation, IgE expression, and cell apoptosis in human and mouse abdominal aortic aneurysm (AAA) lesions. Ang II (angiotensin II)-induced AAA in Nhe1-insufficient Apoe-/-Nhe1+/- mice and Apoe-/-Nhe1+/+...
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