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Article

A Dual Role of Heme Oxygenase-1 in Angiotensin II-Induced Abdominal Aortic Aneurysm in the Normolipidemic Mice.

Cells - 15 Jan 2021

Kopacz Aleksandra, Klóska Damian, Werner Ewa, Hajduk Karolina, Grochot-Przęczek Anna, Józkowicz Alicja, Piechota-Polańczyk Aleksandra

Abstract excerpt

Abdominal aortic aneurysm (AAA) bears a high risk of rupture and sudden death of the patient. The pathogenic mechanisms of AAA remain elusive, and surgical intervention represents the only treatment option. Heme oxygenase-1 (HO-1), a heme degrading enzyme, is induced in AAA, both in mice and humans. HO-1 was reported to mitigate AAA development in an angiotensin II (AngII)-induced model of AAA in hyperlipidemic...

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Identifiers

PMID: 33467682
DOI: 10.3390/cells10010163
PMCID: PMC7830394

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