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Article

Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies.

The journals of gerontology. Series A, Biological sciences and medical sciences - 8 Oct 2018

Bae Harold, Gurinovich Anastasia, Malovini Alberto, Atzmon Gil, Andersen Stacy L, Villa Francesco, Barzilai Nir, Puca Annibale, Perls Thomas T, Sebastiani Paola

Abstract excerpt

Previous studies note specific FOXO3 single-nucleotide polymorphisms (SNPs) associated with human longevity. However, it is not clear if these SNPs influence mortality risk beyond the oldest 1 percentile of survival. Using data from four longevity studies (total n = 8,266, age range 96-119 years for cases), we tested gene-wide association between 107 SNPs and survival to at least the oldest 1 percentile of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28977569
DOI: 10.1093/gerona/glx124
PMCID: PMC6175020

Genes

FOXO3

Provenance

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