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Article

Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cells.

The Journal of experimental medicine - 22 Jan 2007

Riou Catherine, Yassine-Diab Bader, Van grevenynghe Julien, Somogyi Roland, Greller Larry D, Gagnon Dominic, Gimmig Sylvain, Wilkinson Peter, Shi Yu, Cameron Mark J, Campos-Gonzalez Roberto, Balderas Robert S, Kelvin David, Sekaly Rafick-Pierre, Haddad Elias K

Abstract excerpt

The molecular events involved in the establishment and maintenance of CD4+ central memory and effector memory T cells (TCM and TEM, respectively) are poorly understood. In this study, we demonstrate that ex vivo isolated TCM are more resistant to both spontaneous and Fas-induced apoptosis than TEM and have an increased capacity to proliferate and persist in vitro. Using global gene expression profiling, single...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17190839
DOI: 10.1084/jem.20061681
PMCID: PMC2118424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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