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Article

Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cells.

The Journal of experimental medicine - 22 Jan 2007

Riou Catherine, Yassine-Diab Bader, Van grevenynghe Julien, Somogyi Roland, Greller Larry D, Gagnon Dominic, Gimmig Sylvain, Wilkinson Peter, Shi Yu, Cameron Mark J, Campos-Gonzalez Roberto, Balderas Robert S, Kelvin David, Sekaly Rafick-Pierre, Haddad Elias K

Abstract excerpt

The molecular events involved in the establishment and maintenance of CD4+ central memory and effector memory T cells (TCM and TEM, respectively) are poorly understood. In this study, we demonstrate that ex vivo isolated TCM are more resistant to both spontaneous and Fas-induced apoptosis than TE...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17190839
DOI: 10.1084/jem.20061681
PMCID: PMC2118424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17190839-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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