Article
Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.
Antimicrobial agents and chemotherapy - 1 Dec 2017
Nakatani Yoshio, Opel-Reading Helen K, Merker Matthias, Machado Diana, Andres Sönke, Kumar S Siva, Moradigaravand Danesh, Coll Francesc, Perdigão João, Portugal Isabel, Schön Thomas, Nair Dina, Devi K R Uma, Kohl Thomas A, Beckert Patrick, Clark Taane G, Maphalala Gugu, Khumalo Derrick, Diel Roland, Klaos Kadri, Aung Htin Lin, Cook Gregory M, Parkhill Julian, Peacock Sharon J, Swaminathan Soumya, Viveiros Miguel, Niemann Stefan, Krause Kurt L, Köser Claudio U
Abstract excerpt
A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to d-cycloserine.
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