Overexpression of the D-alanine racemase gene confers resistance to D-cycloserine in Mycobacterium smegmatis.

doi:10.1128/jb.179.16.5046-5055.1997

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Article

Overexpression of the D-alanine racemase gene confers resistance to D-cycloserine in Mycobacterium smegmatis.

Journal of bacteriology - 1 Aug 1997

Cáceres N E, Harris N B, Wellehan J F, Feng Z, Kapur V, Barletta R G

Abstract excerpt

D-Cycloserine is an effective second-line drug against Mycobacterium avium and Mycobacterium tuberculosis. To analyze the genetic determinants of D-cycloserine resistance in mycobacteria, a library of a resistant Mycobacterium smegmatis mutant was constructed. A resistant clone harboring a recomb...

Topics

Alanine Racemase
Amino Acid Sequence
Antibiotics, Antitubercular
Cloning, Molecular
Cycloserine
Drug Resistance, Microbial
Gene Expression Regulation, Bacterial
Genomic Library
Molecular Sequence Data
Mutation
Mycobacterium
Mycobacterium avium Complex
Mycobacterium bovis
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PMID: 9260945
DOI: 10.1128/jb.179.16.5046-5055.1997
PMCID: PMC179361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9260945-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Promoter Regions, Genetic

Sequence Alignment